Monitoring of metabolic parameters of mammal cells cultures in microfluidic devices using integrated optical chemical sensors
May 7-10, 2017
Optical chemical sensors are well established in the chemical industry, life science, biotechnology and research laboratories. They are operate non-invasive, do not need any reference elements and can be read-out via contactless measurement. Moreover, it is possible to miniaturize and integrate them into microfluidic systems. Due to their simple composition, optical sensors can be produced at low price and therefore represent a good alternative compared to electrochemical sensors for their application in disposable microfluidics. The various possibilities of integrated optical oxygen sensors have already shown their potential in different microfluidic applications . However, monitoring of further metabolic parameters is important for a better understanding of biological processes. Therefore, our group develops, next to oxygen sensors, also optical sensors for monitoring pH, glucose, CO2, ammonia and various ions. Still, integration in a Lab-on-a-chip format is a challenging task due to the state-of-the-art performances in terms of signal brightness, response times, optoelectronic read-out systems, fabrication and integration.
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Bernhard Mueller, Philipp Sulzer, Martin Strobl, Torsten Mayr, Helene Zirath, Mario Rothbauer, and Peter Ertl, "Monitoring of metabolic parameters of mammal cells cultures in microfluidic devices using integrated optical chemical sensors" in "Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications", kta Mahajan (Genentech, Inc., USA) Gary Lye (University College London, UK) Regine Eibl-Schindler (Zurich University of Applied Science, Switzerland) Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/biopoly_ii/26