Title
Cellular response of CHO cells following exposure to extractables and leachables from single-use bioreactors
Conference Dates
May 7-10, 2017
Recommended Citation
Sara Carillo, Noemí Dorival Garcia, Christine Ta, Jonathan Bones, Niall Barron, Sam Pare, and Paul S. Kelly, "Cellular response of CHO cells following exposure to extractables and leachables from single-use bioreactors" in "Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications", kta Mahajan (Genentech, Inc., USA) Gary Lye (University College London, UK) Regine Eibl-Schindler (Zurich University of Applied Science, Switzerland) Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/biopoly_ii/9
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COinS
Comments
The implementation of single-use disposable bioreactors as alternatives to the dominant stainless steel predecessor used in the manufacturing of recombinant therapeutic proteins introduces a variety of new materials into the bioprocessing pipeline. These plastics, when used under normal culture conditions, can degrade and leach breakdown products into the culture media such as bis(2,4-di-tert-butylphenyl) phosphate (bDtBPP).1,2
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