Photoacoustic imaging as a potential tool for clinical evaluation of Inflammatory arthritis
July 23-26, 2017
Presenting highly sensitive and clinically relevant functional information from soft tissues in and around the joint with spatial resolution comparable to ultrasound (US) imaging, photoacoustic (PA) imaging may shed new light on early diagnosis and treatment evaluation of human inflammatory arthritis. In this study on severe arthritis patients and healthy control subjects, we explored the potential contribution of PA imaging to rheumatology clinic. The feasibility of a point-of-care device built on a LED based PA imaging system for evaluating human finger joints was also studied. By performing imaging at a single laser wavelength, the spatially distributed hemoglobin content reflecting the hyperemia in synovial tissue in the finger joints of arthritis patients were imaged. By performing imaging at two laser wavelengths, the spatially distributed hemoglobin oxygenation reflecting the hypoxia in the finger joints of arthritis patients were also imaged. The measurements from the arthritis patients and the healthy controls were statistically analyzed by using two-tailed student t-tests.
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Xueding Wang, Guan Xu, Sheeja Francis, April Marquardt, and Gandikota Girish, "Photoacoustic imaging as a potential tool for clinical evaluation of Inflammatory arthritis" in "Advances in Optics for Biotechnology, Medicine and Surgery XV", Peter So, Massachusetts Institute of Technology, USA Kate Bechtel, Triple Ring Technologies, USA Ivo Vellekoop, University of Twente, The Netherlands Michael Choma, Yale University, USA Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/biotech_med_xv/26