Title
Confronting the Analytical Challenges of Chimeric Antigen Receptor T Cell
Conference Dates
May 6-11, 2018
Abstract
Intensive research and development effort has been devoted to Chimeric antigen receptor T (CAR-T) cell therapies. CAR-T presents unique challenges for analytical development due to its complex mechanism of actions, large heterogeneity of the starting material, the need for appropriate reference material, and the limited lot size and testing material. This presentation will use Lisocabtagene maraleucel as a case study to illustrate how an integrated analytical strategy enables the development of a late phase CAR-T program
Recommended Citation
Heidi Zhang, "Confronting the Analytical Challenges of Chimeric Antigen Receptor T Cell" in "Cell Culture Engineering XVI", A. Robinson, PhD, Tulane University R. Venkat, PhD, MedImmune E. Schaefer, ScD, J&J Janssen Eds, ECI Symposium Series, (2018). https://dc.engconfintl.org/ccexvi/239