ECI Digital Archives

Title

Online capacitance probes precisely control cell biomass growth through temperature regulation

Authors

Jeffrey Swanberg, Bristol-Myers Squibb Company, USAFollow
Ricardo Lewis, Bristol-Myers Squibb Company, USA
Norman Riker, Bristol-Myers Squibb Company, USA
Kathryn Aron, Bristol-Myers Squibb Company, USA
Michael Borys, Bristol-Myers Squibb Company, USA
Zhengjian Li, Bristol-Myers Squibb Company, USA

Conference Dates

May 6-11, 2018

Abstract

Understanding cell growth is critical for developing efficient and robust bioreactor processes. Due to exponential growth characteristics, small perturbations in process conditions such as inoculation density, media composition, and pH can have large impacts on cell density and process performance. In addition, standard offline measurement techniques fail to capture important data such as the exact density and timing of peak cell growth. This makes process decisions based on cell density, such as temperature shifting, difficult to time. Online capacitance probes offer unique opportunities to understand and control mammalian cell culture processes in real time.

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Recommended Citation

Jeffrey Swanberg, Ricardo Lewis, Norman Riker, Kathryn Aron, Michael Borys, and Zhengjian Li, "Online capacitance probes precisely control cell biomass growth through temperature regulation" in "Cell Culture Engineering XVI", A. Robinson, PhD, Tulane University R. Venkat, PhD, MedImmune E. Schaefer, ScD, J&J Janssen Eds, ECI Symposium Series, (2018). https://dc.engconfintl.org/ccexvi/99