Engineering stem cell fate for drug development and therapy
January 15-19, 2017
We have developed a robust closed-system bioprocess that combines a “fed-batch” (FB) media dilution strategy with a first-in-class hematopoietic stem cell (HSC) stimulating small molecule (called UM171) to expand functional umbilical cord blood (UCB)-derived HSCs and progenitors to clinically relevant levels. The feasibility, safety and efficacy of our FB+UM171-expanded cells for adult allogeneic transplantation are being tested in a funded Phase I/II clinical trial based at the Hôpital Maisonneuve-Rosemont in Montreal. In this presentation we will review our development work to generate robust procedures for clinical blood cell manufacturing and provide insight into the development of our next-generation bioprocesses that will enable personalized, cost-effective and automated blood progenitors cell production in centres across Canada.
Peter Zandstra and Guy Sauvageau, "Engineering stem cell fate for drug development and therapy" in "Scale-up and Manufacturing of Cell-based Therapies V", Tom Brieva, Celgene Cellular Therapeutics William Miller, Northwestern University Chris Mason, University College London Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/cellbasedtherapies_v/81