Exosomes For Regenerative Medicine – Manufacturing Challenges And Potential Applications
January 15-19, 2017
Extracellular vesicles, or exosomes, are emerging as a novel class of therapeutic that confer many of the regenerative functions originally ascribed to the cells that produce them. From their emergence as possible biomarkers of diseases such as cancer they have rapidly emerged as candidate regenerative medicines. The potential market for exosomes is huge, spanning a range of clinical indications that stem cells have been expected to be utilized for. Overwhelmingly positive pre-clinical data on the effectiveness of exosomes has underpinned this excitement, yet there remain some substantial manufacturing challenges that relate to scale of production and reliability in measurement and characterization of exosome material. In particular, challenges of purifying exosomes at scale whilst preserving their therapeutic attributes need to be overcome to ensure products can be made consistently. The talk will introduce exosomes and their potential applications in regenerative medicine and consider the current manufacturing challenges that researchers are now starting to tackle.
Ivan Wall, "Exosomes For Regenerative Medicine – Manufacturing Challenges And Potential Applications" in "Scale-up and Manufacturing of Cell-based Therapies V", Tom Brieva, Celgene Cellular Therapeutics William Miller, Northwestern University Chris Mason, University College London Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/cellbasedtherapies_v/90
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