Cubosomes as potential theranostic tools
July 10-14, 2016
Application of nanotechnology to medicine offers a versatile approach for the design and the development of new multi-functional drug delivery systems where imaging probes, drugs, and targeting agents can be combined and applied as therapeutic/diagnostic (theranostic) tools. Furthermore, this application requires the development of biocompatible and non-toxic systems with tunable properties.
Here, monoolein-based nanoparticles known as cubosomes are proposed as theranostic platform in nanomedicine. These nanoparticles show high structural stability and, because of their intrinsic nanostructure, can be loaded with hydrophobic cargos. It will be shown that cubosomes can effectively be loaded with anticancer drugs, UV-visible or NIR emitting fluorophores, while simultaneously conjugated with cells-targeting ligands. Their living cells imaging skills, addressing abilities toward HeLa cells, as well as biodistribution in vivo will be also presented.
Please click Additional Files below to see the full abstract.
Sergio Murgia, "Cubosomes as potential theranostic tools" in "Colloidal, Macromolecular & Biological Gels: Formulation, Properties & Applications", ECI Symposium Series, (2016). http://dc.engconfintl.org/cmb_gels/15