In-vivo evaluation of biocompatibility of biodegradable Fe-Mn materials
November 12-16, 2017
The authors evaluated the biodegradability and biocompatibility of an alloy of iron and manganese in a bone model in vivo. Fe-Mn biodegradable materials with various porosities were first fabricated and characterized for microstructure, corrosion and mechanical properties.
Resorption of a bioabsorbable wire of chemical formula Fe30Mn and no induced porosity was evaluated in-vivo. The Fe-Mn alloy behavior in-vivo was compared to that of a traditional permanent 316L stainless steel (SS) wire after bilateral transcondylar femoral implantation in 12 rats. Evaluation of biodegradation was performed over a period of 6 months using serial radiography, post-mortem histology and macroscopic implant surface analysis. Increased bone ingrowth was noted at the iron-manganese wire-bone interface, which indicates increased osseointegration of the implant.
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Sabrina Huang, Marine Traverson, Michael Heiden, Lia A. Stanciu, Eric A. Nauman, Gert J. Breur, and Yava Jones-Hall, "In-vivo evaluation of biocompatibility of biodegradable Fe-Mn materials" in "Composites at Lake Louise 2017", Eric Duoss, Lawrence Livermore National Laboratory, USA Waltraud M. Kriven, University of Illinois at Urbana-Champaign, USA Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/composites_all_2017/18