Multi-method in-vitro and in-vivo evaluation of coacervation and deposition behavior in cleansing formulations
July 22-25, 2018
The inclusion of cationic polymers in cleansing formulations is a commonly utilized practice to provide conditioned after-feel to skin and hair and increase the efficiency of insoluble benefit agent deposition. However, predicting the efficiency of polymer-surfactant complexation (coacervation) and the resulting deposition efficacy of polymer complexes and insoluble actives purely from formulation components remains a challenge, due to the complex interactions of polymer, surfactant and solution properties. In this work, we validate and implement multiple methods for rapidly screening and quantifying dilution-induced polymer precipitation and deposition in cleansing formulations. We then utilize these methods to verify and compare deposition behavior in several well-utilized polymer-surfactant systems and commercial cleansing products.
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Matthew A. Lohr and Tobias Futterer, "Multi-method in-vitro and in-vivo evaluation of coacervation and deposition behavior in cleansing formulations" in "Advances in Cosmetic Formulation Design", ECI Symposium Series, (2018). http://dc.engconfintl.org/cosmetic/8