In vitro characterization of a biodegradable chitosan/bioactive glass coating for Mg alloys
October 1-6, 2017
Magnesium and its alloys have already been proposed for biomedical applications in 1878. However, up to date no extended, successful medical Mg product is commercially available. The drawbacks of permanent implants, like stress-shielding or possible release of metal ions through wear, can be avoided with the use of biodegradable metals. Temporary implants as such could make a second surgical process to remove the implant unnecessary, not only decreasing the healthcare costs and associated risks of a surgery, but also reducing the trauma to the patient.
Mg is an abundant cation in the human body and in part physiologically beneficial as the surrounding tissue can absorb and consume the ions. The main problems related to the usage of Mg and its alloys is its high chemical reactivity, a related low corrosion resistance, especially in chloride-containing environments and the accompanying fast hydrogen gas production. 
In order to overcome these problems in this study a coating of a natural polymer/bioactive glass composite is applied using electrophoretic deposition. Additionally, functional properties like drug delivery characteristics and antibacterial capacity are added to these coatings.
As natural, cationic polymer chitosan is taken which is the supporting material in the exoskeleton of crustaceans and insects (crab, butterfly) and in cell walls of fungi. It combines biodegradability and biocompatibility with the ability to promote cell adhesion. 
To avoid dissolution of the Mg alloy substrate during the deposition, a pretreatment is used. The immersion in DMEM for 24 h is increasing the corrosion resistance to a level that the acidic, aqueous electrolyte during deposition is not corroding the Mg substrate.  A comparative study was performed on replacing part of the bioactive glass as ceramic part with silica particles in order to maintain a topography during dissolution of the glass. A constant solid content of 1 g/l was chosen, with 0.5 g/l chitosan in 1 vol% acetic acid, 20 vol% water and 79 vol% ethanol following previous studies.  For the cathodic deposition process 0.5 cm electrode distance with stainless steel as the counter electrode was used. The deposition was performed under constant current (50 V) and constant voltage (35 mA) with varying processing times.
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 Cordero-Arias, L. et al. 2013 Electrophoretic deposition of nanostructured-TiO2/Chitosan composite coatings on stainless steel. R. Soc. Chem. 3, 11247-11254
Acknowledgements: This study is supported by the German Science Foundation (DFG).
Svenja Heise, T. Wirth, M. Hoehlinger, V. Wagener, S. Virtanen, A.R. Boccaccini, and H. Hornberger, "In vitro characterization of a biodegradable chitosan/bioactive glass coating for Mg alloys" in "Electrophoretic Deposition VI: Fundamentals and Applications", Aldo R. Boccaccini, Institute of Biomaterials, University of Erlangen-Nuremberg, Germany Omer van der Biest, Department of Metallurgy and Materials Engineering, Katholieke Universiteit Leuven, Belgium James Dickerson, Consumer Reports, USA Tetsuo Uchikoshi, National Institute for Materials Science, Japan Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/electrophoretic_vi/26