Enzymatic glycosylation of Ellagic acid
September 24-28, 2017
Ellagic acid is a natural biomolecule with several biological propertiesi such as anti-oxidant activity. However the poor solubility of this compound limits its bioavailability and its potential for pharmaceutical or cosmetic application.ii It’s well-known that glycosylation can significantly improve the physicochemical and biological properties of small molecules.iii Enzymatic glycosylation of this compound would be a solution to access a more soluble ellagic acid through a sustainable and environmentally friendly process. Glucansucrases, that use sucrose as donor substrate to transfer a glucose unit, are highly promising catalysts to glycosylate high valuated biomolecules.iv
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Maude Brossat, Laure Guillotin, Magali Remaud-Simeon, Sandrine Morel, and Cosima Dufour, "Enzymatic glycosylation of Ellagic acid" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/enzyme_xxiv/134