The fourth dimension: Accounting for dynamics when engineering enzymes
September 24-28, 2017
Despite key advances in enzyme engineering, our capacity to predict the effects of mutations on function remains nebulous. A central consideration in our incapacity to predict sequence-function relationships is the fact that proteins are dynamic, yet we rarely treat them as such.
Please click Additional Files below to see the full abstract.
Joelle Pelletier, "The fourth dimension: Accounting for dynamics when engineering enzymes" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/enzyme_xxiv/160