Switching the cofactor specificity of an imine reductase
September 24-28, 2017
Chiral amines have proven to be powerful building blocks for defining new pharmaceutical and agrochemicals due to their high density of structural information. In this light, the reduction of prochiral C=N double bonds is a well-established route in synthetic chemistry due to the easy accessibility of imines from their ketone precursors with the asymmetric addition of hydrogen or a hydride as the key stereo-differentiating step. Recently, we have witnessed remarkable advances in the enzyme-catalyzed asymmetric reduction of imines by NADPH-dependent imine reductases (IREDs).[1,2] Imine reductases were presented that catalyze the asymmetric reduction of various imines and the chemo- and stereoselective reductive amination as a useful method for the preparation of amines derived from aldehydes and ketones.[3,4]
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Bettina M. Nestl and Niels Borlinghaus, "Switching the cofactor specificity of an imine reductase" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). http://dc.engconfintl.org/enzyme_xxiv/69