Ultrasmall hexagonal NaGdF4:Yb nanoparticles: A theranostic approach to radiotherapy
July 3-7, 2016
Uniform sub 5-nm β-NaGdF4:Yb nanoparticles as bimodal contrast agent for T1 MRI and CT have exhibited dual imaging capability comparable to the commercially available contrast agents for both MRI (i.e. Gd-DTPA) and CT (i.e. Iohexol) modalities. In addition, these nanoparticles can act as radiosensitizer resulting in a significant cell reproductive death after irradiation. In the absence of irradiation treatment, no adverse effects were observed in the cells incubated with the nanoparticles, as further confirmed by MTS assay. These indicate good potential as theranostic agent to facilitate targeted radiation therapy for optimal eradication of tumor cells with minimal damage to the surrounding normal cells. Looking at the biodistribution of these nanoparticles based on ex vivo analysis of Gd3+ ions via ICP-MS implies body clearance through urine and feces within a reasonable timescale. Given all these properties, these ultrasmall NaGdF4:Yb nanoparticles can serve as a good candidate for the development and design of image-guided radiotherapy.
Jossana Damasco, Tymish Ohulchanskyy, Guanying Chen, Haoyuan Huang, Supriya Mahajan, Timothy Winslow, Jonathan Lovell, and Paras Prasad, "Ultrasmall hexagonal NaGdF4:Yb nanoparticles: A theranostic approach to radiotherapy" in "Nanotechnology in Medicine: From Molecules to Humans", Prof. Lola Eniola-Adefeso, Department of Chemical Engineering, University of Michigan, USA Prof. Paolo Decuzzi, Italian Institute of Technology, Italy Eds, ECI Symposium Series, (2016). http://dc.engconfintl.org/nanotech_med/37