Acoustic enhancement of intracellular delivery for ex vivo therapeutics
June 5-9, 2018
Recent advances in gene editing and therapy have highlighted the potential of ex vivo cell-based techniques to treat many diseases, wherein a patient’s cells are harvested, engineered to insert various therapeutic agents such as nucleic acids or proteins, and re-infused. Considerable challenges however remain in the ability not just to insert these agents into cells whilst retaining high levels of cellular viability, but also to ensure that they are not lysed within the cell.
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Leslie Yeo, Christina Cortez-Jugo, Amgad Rezk, and Shwathy Ramesan, "Acoustic enhancement of intracellular delivery for ex vivo therapeutics" in "Nanotechnology in Medicine II: Bridging Translational in vitro and in vivo Interfaces", Millicent Sullivan, PhD, University of Delaware, USA Josué Sznitman, Dr. Sc., Technion-Israel Institute of Technology, Israel Lola Eniola-Adefeso, PhD, University of Michigan, USA Srivatsan Kidambi, PhD, University of Nebraska - Lincoln, USA Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/nanotech_med_ii/28