Photothermal therapy generates a thermal window of immunogenic cell death in neuroblastoma
June 5-9, 2018
Nanoparticle-based photothermal therapy (PTT) has been widely investigated in cancer therapy as a rapid and minimally invasive tumor ablation technique. Over the past two decades, several reports utilizing nanoparticles for PTT of diverse tumor types in vitro and in vivo have been described. An emerging area of interest is the effect of PTT on the immune system during tumor therapy, since PTT not only causes tumor cell death, but can also release tumor antigens and endogenous adjuvants (e.g. heat shock proteins, damage-associated molecular patterns (DAMPs)) under certain conditions. These effects have the potential to increase tumor immunogenicity, which can trigger improved therapeutic responses. Engaging the immune system during PTT is important as it offers the potential for persistent treatment responses and immunological memory.
Here, we describe a thermal “window” of immunogenic cell death (ICD) elicited by nanoparticle-based photothermal therapy (PTT) in an animal model of neuroblastoma.
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Rohan Fernandesrfernandes@gwu.edu, Elizabeth E. Sweeney, and Juliana Cano-Mejia, "Photothermal therapy generates a thermal window of immunogenic cell death in neuroblastoma" in "Nanotechnology in Medicine II: Bridging Translational in vitro and in vivo Interfaces", Millicent Sullivan, PhD, University of Delaware, USA Josué Sznitman, Dr. Sc., Technion-Israel Institute of Technology, Israel Lola Eniola-Adefeso, PhD, University of Michigan, USA Srivatsan Kidambi, PhD, University of Nebraska - Lincoln, USA Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/nanotech_med_ii/44