Genetically encoded polymers for drug delivery
June 5-9, 2018
I will highlight two technologies developed in my laboratory for the delivery of diverse drugs by genetically encoded polymer drug carriers. First, I will describe a new drug delivery system that we have developed for small molecule cancer chemotherapeutics. This methodology —attachment-triggered self-assembly of recombinant peptide polymers— can package small molecule cancer drugs with a range of hydrophobicity into soluble nanoparticles of a recombinant peptide polymer. These nanoparticles increase the solubility, plasma half-life, and tumor accumulation of the drug, which translates to improved efficacy of the nanoparticle formulation as compared to free drug. Examples of encapsulating doxorubicin, paclitaxel, and gemcitabine —three drugs with vastly different structures and physico-chemical properties— will be presented to illustrate the versatility of this new technology for drug delivery. I will also discuss an injectable delivery system based on thermally sensitive polypeptides for the sustained and tunable release of peptide drugs from a subcutaneous injection site that we have developed for treatment of type 2 diabetes.
Ashutosh Chilkoti, "Genetically encoded polymers for drug delivery" in "Nanotechnology in Medicine II: Bridging Translational in vitro and in vivo Interfaces", Millicent Sullivan, PhD, University of Delaware, USA Josué Sznitman, Dr. Sc., Technion-Israel Institute of Technology, Israel Lola Eniola-Adefeso, PhD, University of Michigan, USA Srivatsan Kidambi, PhD, University of Nebraska - Lincoln, USA Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/nanotech_med_ii/46