Injectable hyaluronic acid based hydrogels for the repair of cartilage lesions
May 20-25, 2018
Hyaluronic acid (HA) is a natural polysaccharide which is found natively in cartilage tissue. HA hydrogels are formed by the modification of HA through its carboxyl and hydroxyl groups and subsequent crosslinking. For applications in cartilage repair, it has been found that HA hydrogels not only support and maintain chondrocyte viability and phenotype when cultured in vitro and in vivo, but also that HA hydrogel chemistry supports and promotes the chondrogenic differentiation of mesenchymal stem cells (MSCs). A promising, non-invasive method for the repair of cartilage lesions is based on the use of injectable hydrogels with desirable properties in combination with biomolecules and cells.
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Costas Kiparissides, Evgenia Tsanaktsidou, and Olga Kammona, "Injectable hyaluronic acid based hydrogels for the repair of cartilage lesions" in "Polymer Reaction Engineering X (PRE 10)", John Tsavalas, University of New Hampshire, USA Fouad Teymour, Illinois Institute of Technology, USA Jeffrey Stubbs, HP Inc., USA Jose R. Leiza, University of the Basque Country, Spain Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/prex/43