Biocompatible superparamagnetic poly(thioether-ester) nanoparticles via miniemulsion technique
May 20-25, 2018
Biocompatible polymeric nanoparticles were obtained via thiol-ene polymerization of a biobased monomer in miniemulsion. The α,ω-diene-diester monomer was synthesized through esterification reaction of a glycerol derivative, namely 1,3-propanediol, with 10-undecenoic acid, a long-chain diene carboxylic acid. The biobased poly(thioether-ester), PTEE, nanoparticles were submitted to cytotoxicity and hemolysis analyses. High cell viability and no significant changes in cell morphology were observed. Lastly, hemolysis assays revealed blood compatibility and therefore PTEE nanoparticles have been shown to be a potential alternative drug delivery vector for intravenous administration. The poly(thioether-ester) was also employed to encapsulate magnetic nanoparticles (MNPs) by miniemulsification technique.
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Pedro Henrique Hermes de Araújo, Paula Christina Mattos dos Santos, Paulo Emilio Feuser, Priscilla Barreto Cardoso, and Claudia Sayer, "Biocompatible superparamagnetic poly(thioether-ester) nanoparticles via miniemulsion technique" in "Polymer Reaction Engineering X (PRE 10)", John Tsavalas, University of New Hampshire, USA Fouad Teymour, Illinois Institute of Technology, USA Jeffrey Stubbs, HP Inc., USA Jose R. Leiza, University of the Basque Country, Spain Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/prex/7