September 23-26, 2018
The elimination of high temperature and high pressure sterilization processes by the advent of Single-Use-Systems (SUS) opens up a new era for the glass electrode based pH sensor. Without the requirement for pretreatment of a pH glass electrode under high temperature and pressure, the classic pH sensing technology delivers a more reliable, more rugged, and more accurate pH measurement. However, the innovative and unique SUS practice also posts new challenges, such as the long shelf-life requirement and the limitation of access to the sensor for calibration once on site,.
At Broadley-James Corporation, a new manufacturing technology has been developed to allow a coplanar pH glass electrode design. This innovative sensor design will allow the sensing surface to transfer from a storage/calibration position to a measurement position while maintaining a fully closed and sterile system status. A single use pH sensor based on this design exhibits features such as shelf life up to 2 years post gamma, on site calibration capability, post use validation capability, and 2 – 12 pH range coverage. This poster will present a coplanar tubular glass electrode design for upstream (bag) installation, as well as a coplanar flat glass electrode design for downstream (flow path) installation. Sensor accuracy verification, design details, and preliminary test results will also be presented.
CD Feng and Robert Garrahy, "Single-Use pH sensor via a coplanar pH glass electrode design" in "Single-Use Technologies III: Scientific and Technological Advancements", Weibing Ding, Amgen Martina Micheletti, University College London Robert Repetto, Pfizer Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/sut_iii/27