Study of accuracy and selectivity of a hydrogel-based sensor array by Design of Experiments (DOE)
September 23-26, 2018
Reliable continuous sensors are salient to achieving advanced Process Analytical Technologies in the bioproduction industry. Sensors provide information on key parameters in a bioreactor such as physical variables (temperature, pressure, speed of stirrer), chemical variables (pH, pO2, pCO2, nutrients, metabolites), and biological variables (biomass, cell metabolism).1-2 Simultaneously, chemometric analysis using multivariate data analysis, bioprocess modeling, and design of experiments (DOE) have become important in developing advanced biosensors because of the need to clean the complex raw data from biosensors to provide repeatable, robust, and reliable information.3-4 In this work, the first step of the chemometric analysis process, DOE was performed with a prototype biosensor developed to simultaneously monitor glucose, lactate, pH, and osmolarity to understand the accuracy and selectivity of this sensor.
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Prashant Tathireddy, Rohit Sharma, Nick Frazier, Seung Hei Cho, Yoonsung Goo, Derik West, and Jules J. Magda, "Study of accuracy and selectivity of a hydrogel-based sensor array by Design of Experiments (DOE)" in "Single-Use Technologies III: Scientific and Technological Advancements", Weibing Ding, Amgen Martina Micheletti, University College London Robert Repetto, Pfizer Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/sut_iii/28