Transitioning to facility using Single Use Technology (SUT)
September 23-26, 2018
Establishing comparability in SUT facilities for processes that were previously run in stainless steel facilities can be a challenge. This poster will document a case study for demonstrating cell culture performance and product quality comparability for a process transitioning into a SUT facility. Experiments that were conducted to test rocking WAVE bioreactor systems to replace stirred tank bioreactors for seed stage will be described. Results from lab and pilot scale experiments to test bag films that will be used in the inoculum and production bioreactors will be presented. Results from preliminary experiments to test the effect of nanofiltration of cell culture medium will also be discussed.
Karthik Veeravalli, Vinson Tan, Ganesh Vissvesvaran, Asiedua Asante, and Ralph Von Daeniken, "Transitioning to facility using Single Use Technology (SUT)" in "Single-Use Technologies III: Scientific and Technological Advancements", Weibing Ding, Amgen Martina Micheletti, University College London Robert Repetto, Pfizer Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/sut_iii/4