June 6-11, 2010
The ISCOMATRIX™ adjuvant has antigen delivery and presentation properties as well as immunomodulatory capabilities which combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of sub classes of antibodies as well as both CD4+ and CD8+ T cells. A range of ISCOMATRIX™ vaccines (ISCOMATRIX™ adjuvant combined with antigen) have now been tested in clinical trials and have been shown to be generally safe and well tolerated as well as immunogenic, generating both antibody and T cell responses.
The mechanisms by which ISCOMATRIX™ adjuvant facilitates its immune effects is the scope of significant study and indicates that ISCOMATRIX™ adjuvant (i) rapidly traffics antigen into the cytosol of multiple dendritic cell subsets, (ii) induces the induction of an array of cytokines and chemokines and (iii) links the innate and adaptive immune responses in vivo in a TLR-independent but MyD88-dependent manner. These data highlight the clinical utility of ISCOMATRIX™ adjuvant in the development of novel prophylactic and therapeutic vaccines.
Debbie Drane, "ISCOMATRIX™ ADJUVANT LINKS INNATE AND ADAPTIVE IMMUNE RESPONSES" in "Vaccine Technology III", John G. Auniņš,Merck, USA; Barry C. Buckland, BiologicB, USA; Kathrin U. Jansen, Pfizer, USA; Paula Marques Alves, IBET, Portugal Eds, ECI Symposium Series, (2010). http://dc.engconfintl.org/vaccine_iii/3