Computational fluid dynamics modeling for HPV fermentation bioreactors
June 12-17, 2016
The fermentation processes for the manufacture of HPV (GARDASIL AND GARDASIL 9) are currently conducted at multiple manufacturing scales. The goal of the bioreactor modeling project for HPV is to generate data and models to support robust manufacturing and process understanding initiatives across the multiple scales. Additionally, this knowledge can be utilized to aid in future process transfers. The modeling work is performed utilizing computer models (Computational Fluid Dynamics via Fluent) and historical data to predict metabolic behavior based on bioreactor configurations and processing conditions.
Tracie Spangler and Matthew Flamm, "Computational fluid dynamics modeling for HPV fermentation bioreactors" in "Vaccine Technology VI", Laura Palomares, UNAM, Mexico Manon Cox, Protein Sciences Corporation, USA Tarit Mukhopadhyay, University College London, UK Nathalie Garçon, BIOASTER Technology Research Institute, FR Eds, ECI Symposium Series, (2016). http://dc.engconfintl.org/vaccine_vi/48