Continuous purification of cell culture-derived influenza A virus particles through pseudo- affinity membrane chromatography
June 17-22, 2018
Continuous manufacturing is a relevant trend in biopharmaceutical production to reduce the process footprint and to improve the process economy. Vaccines against world-spread diseases, such as influenza, should benefit in particular from such an approach, given the increasing demand for seasonal vaccines and the need for a fast response in case of a pandemic outbreak. Upstream processing of viral vaccines has seen important progress in continuous production of viral vaccines , which further supports the development of hybrid or fully continuous flow-schemes for downstream processing.
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A. Raquel Fortuna, Florian Taft, Louis Villain, Michael W. Wolff, and Udo Reichl, "Continuous purification of cell culture-derived influenza A virus particles through pseudo- affinity membrane chromatography" in "Vaccine Technology VII", Amine Kamen, McGill University Tarit Mukhopadhyay, University College London Nathalie Garcon, Bioaster Charles Lutsch, Sanofi Pasteur Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/vt_vii/124