Upstream process intensification using Viral Sensitizer technology
June 17-22, 2018
Upstream process intensification technologies will play an increasingly important role to cater to growing global demands in vaccines and other viroceuticals including gene therapy vectors and oncolytic viruses. We have discovered and developed viral sensitizer technology, a collection of compounds that improve virus growth with potential utility in a multitude of applications, including manufacturing. We have found that viral sensitizer formulations enhance viral production to varying extents depending on the virus and manufacturing substrate. Productivity can be improved substantially in commonly used production cell lines. In cell culture applications, viral sensitizers can be combined with other process intensification technologies including fixed bed macrocarrier-based bioreactors, as well as commercially available serum-free media and growth supplements. To support commercial implementation, we have developed analytical tools to track compounds during production.
Jean-Simon Diallo, "Upstream process intensification using Viral Sensitizer technology" in "Vaccine Technology VII", Amine Kamen, McGill University Tarit Mukhopadhyay, University College London Nathalie Garcon, Bioaster Charles Lutsch, Sanofi Pasteur Eds, ECI Symposium Series, (2018). http://dc.engconfintl.org/vt_vii/44