Manifestation of one-patch attractive protein interactions in solution scattering and in solution structures

Conference Dates

July 31-August 4, 2017


In this work, we show how static structure factors, obtained from small-angle X-ray scattering and static light scattering shed light as to how patchy, attractive interactions between globular proteins are manifested experimentally and can be distinguished from isotropic attractions. Furthermore, the data are well described by an integral equation theory due to Wertheim for associating liquids, which shows how the patch-patch attraction gives rise to a concentration-driven association into dimers, which to our knowledge has not been shown previously for a biologically relevant system. This fundamental study shows how proteins interactions under the right set of conditions become highly anisotropic and patchy and how this leads to a concentration-induced dimerization, which at yet higher concentrations lead to stripe-like structures being formed.

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