Engineering the adenylate cyclase toxin for use as a bordetella pertussis vaccine antigen
July 16-20, 2017
Bordetella pertussis, the causative agent of whooping cough, was nearly eradicated upon the introduction of a vaccine in the 1920s. This whole cell vaccine was highly immunogenic and thus was replaced by an acellular vaccine in the mid-1990s. In recent decades, infection rates have risen dramatically in industrialized countries reaching a 60-year US high in 2012. Worldwide, B. pertussis remains a major cause of infant death, claiming approximately 195,000 lives annually. This appears partially due to shortcomings of the current vaccine, which confers short-term immunity and seems to prevent the symptoms of disease but not its spread.
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Andrea M. DiVenere, "Engineering the adenylate cyclase toxin for use as a bordetella pertussis vaccine antigen" in "Biochemical and Molecular Engineering XX", Wilfred Chen, University of Delaware, USA Nicole Borth, Universität für Bodenkultur, Vienna, Austria Stefanos Grammatikos, UCB Pharma, Belgium Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/biochem_xx/1