Engineering the adenylate cyclase toxin for use as a bordetella pertussis vaccine antigen

Conference Dates

July 16-20, 2017


Bordetella pertussis, the causative agent of whooping cough, was nearly eradicated upon the introduction of a vaccine in the 1920s. This whole cell vaccine was highly immunogenic and thus was replaced by an acellular vaccine in the mid-1990s. In recent decades, infection rates have risen dramatically in industrialized countries reaching a 60-year US high in 2012. Worldwide, B. pertussis remains a major cause of infant death, claiming approximately 195,000 lives annually. This appears partially due to shortcomings of the current vaccine, which confers short-term immunity and seems to prevent the symptoms of disease but not its spread.

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