A platform technology for dynamic control of cell behavior
July 14-18, 2019
Mammalian cells rely on complex and highly dynamic gene networks to maintain cellular homeostasis in response to environmental stimuli and intracellular signals. Efficient cellular reprogramming thus requires integration of exogenous components for cell engineering with endogenous cellular networks through feedback control systems. We explored the use of post-translational tools for superior feedback regulation of dynamic behaviors. Specifically, we demonstrated efficient detection and manipulation of the main cellular stress response system – the Unfolded Protein Response (UPR) – for the design of high producing cell lines for protein manufacturing and for the development of cell therapies for sustained protein production.
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Laura Segatori, "A platform technology for dynamic control of cell behavior" in "Biochemical and Molecular Engineering XXI", Christina Chan, Michigan State University, USA Mattheos Koffas, RPI, USA Steffen Schaffer, Evonik Industries, Germany Rashmi Kshirsagar, Biogen, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/biochem_xxi/102