Tailoring Corynebacterium glutamicum towards efficient production of plant polyphenols

Conference Dates

July 14-18, 2019


Corynebacterium glutamicum is an important organism in industrial biotechnology for the microbial production of bulk chemicals, in particular amino acids. Functional integration of plant-derived biosynthetic pathways also allows for the microbial synthesis of various plant polyphenols such as flavonoids or stilbenes either from supplemented phenylpropanoid precursor molecules or directly from glucose. However, similar to other microorganisms engineered for plant polyphenol synthesis, insufficient malonyl-CoA supply is also limiting polyphenol production with C. glutamicum. To date, the antibiotic cerulenin inhibiting fatty acid synthesis is added during microbial cultivations to improve malonyl-CoA availability for product formation at lab-scale. Unfortunately, supplementation of cerulenin is very costly, which prohibits large-scale microbial polyphenol production.

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