Title
Fully integrated continuous antibody processing demonstrates improved productivity
Conference Dates
September 17-21, 2017
Abstract
Continuous processing has been an important topic in the biopharmaceutical industry for the past few years. However, as this technology is still at an early stage, continuous processing has remained largely siloed to individual steps with little thought towards combining each stage to create a fully continuous process. This presentation will show a fully integrated continuous process, from production bioreactor to drug substance at pilot scale, as well as touch on considerations for manufacturing costs and facility throughput. Specific emphasis will be given towards the production perfusion bioreactor, capture using multicolumn chromatography, viral inactivation, and buffer exchange.
Recommended Citation
Kenneth Lee, Joanna Pezzini, Lindsay Arnold, Jeong Lee, Jim Dyer, Venkat Raghavan, and Jean Bender, "Fully integrated continuous antibody processing demonstrates improved productivity" in "Integrated Continuous Biomanufacturing III", Suzanne Farid, University College London, United Kingdom Chetan Goudar, Amgen, USA Paula Alves, IBET, Portugal Veena Warikoo, Axcella Health, Inc., USA Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/biomanufact_iii/72