Model-based evaluation and process development of continuous chromatography
October 6-10, 2019
Multi-column periodic counter-current (PCC) chromatography has been proposed as continuous capturing technology to improve the process productivity and resin capacity utilization, as well as reduce buffer consumption and equipment footprint, which is applying for monoclonal antibody (mAb) capture with Protein A affinity resin. Due to the complexity of continues chromatography, some mathematical framework should be developed to aid the process development.
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Dong-Qiang Lin, Ce Shi, and Shan-Jing Yao, "Model-based evaluation and process development of continuous chromatography" in "Integrated Continuous Biomanufacturing IV", Veena Warikoo, Roche, USA Alois Jungbauer, BOKU, Austria Jon Coffman, Boehringer Ingelheim, USA Jason Walther, Sanofi, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/biomanufact_iv/11