Conference Dates

October 6-10, 2019


In the biopharmaceutical market, there is an increasing pressure to reduce prices. Nowadays, a big part of the manufacturing cost is due to the product purification. A big effort has been made in this matter to reduce costs, and continuous downstream processes like periodic counter-current chromatography (PCC) have gained interest in the last years due to a higher productivity and resin utilization compared to a batch process. Herein, a PCC process is integrated with a virus inactivation and two ion-exchange chromatography steps (polishing steps) for the purification of mAb at lab scale, and multi-objective optimization is used to compare several process configurations using two resins with different particle sizes.

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