Continuous virus inactivation using a packed-bed reactor
October 6-10, 2019
A critical unit operation in integrated continuous biomanufacturing is continuous virus inactivation. These reactors must provide sufficient minimum inactivation time and must have a narrow residence time. The narrow residence time is required to avoid a too short or too long incubation. Too short incubation may result in insufficient inactivation, too long may result in partial product destruction. We have developed a packed-bed continuous virus inactivation reactor (CVIR, Figure 1) with significant advantages over other continuous processing approaches, namely scalability, ease of operation and being truly continuous with undisrupted mass flow. The residence time distribution of our reactor is smaller compared to a coiled flow inverter or a jig in a box reactor.
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Duarte L. Martins, Nikolaus Hammerschmidt, Björn Tille, Johanna Kindermann, Thomas R. Kreil, and Alois Jungbauer, "Continuous virus inactivation using a packed-bed reactor" in "Integrated Continuous Biomanufacturing IV", Veena Warikoo, Roche, USA Alois Jungbauer, BOKU, Austria Jon Coffman, Boehringer Ingelheim, USA Jason Walther, Sanofi, USA Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/biomanufact_iv/63