Cellular response of CHO cells following exposure to extractables and leachables from single-use bioreactors

Conference Dates

May 7-10, 2017


The implementation of single-use disposable bioreactors as alternatives to the dominant stainless steel predecessor used in the manufacturing of recombinant therapeutic proteins introduces a variety of new materials into the bioprocessing pipeline. These plastics, when used under normal culture conditions, can degrade and leach breakdown products into the culture media such as bis(2,4-di-tert-butylphenyl) phosphate (bDtBPP).1,2

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