Scalable and cost-effective optical components for biosensing applications
July 23-26, 2017
Cost-effectiveness has been a key factor in consumer biophotonics. In this talk, I will discuss two approaches for overall cost reduction. First, I will introduce a highly porous yet monolithic plasmonic nanosurface that features intense and high-density hot spots, large surface area, and high structural integrity and reproducibility. The fabrication process of this nanosurface is of low-cost and highly scalable. Using localized surface plasmon resonance (LSPR) and coupling modes, enhanced light-matter interactions near the nanosurface can be realized. The surface enhancement results in stronger signal which reduces the burden on high-end optical detection systems. We have applied them to several analytical Chem/Biosensing platforms for a range of sensing targets by various spectroscopic and imaging techniques. Nanoplasmonic sensors appear to provide potential solutions in a range of applications from precision medicine to point-of-care diagnostics and wearable technologies. In the second approach, we have developed an “inkjet printing” process for making polymer lenses which enable high quality microscopic imaging using smartphones – High performance microscopy of nanoscale objects and molecular species can be carried out on $10 phones. Finally, I will discuss the synergy of plasmonic enhancement and smartphone microscopy in the context of consumer biophotonics.
Wei-Chuan Shih, "Scalable and cost-effective optical components for biosensing applications" in "Advances in Optics for Biotechnology, Medicine and Surgery XV", Peter So, Massachusetts Institute of Technology, USA Kate Bechtel, Triple Ring Technologies, USA Ivo Vellekoop, University of Twente, The Netherlands Michael Choma, Yale University, USA Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/biotech_med_xv/29