Radiation-optical interactions

Conference Dates

June 2-6, 2019


The convergence of photonics with nanotechnology and/or ionizing radiation offers new capabilities for biomedical applications. Thus, in the photonics-nano convergence, nanoparticles can be used for a range of purposes: to enhance or spatially localize light-based treatments such as in phototherapy or photodynamic therapy; for targeted delivery of photoactive drugs such as photodynamic sensitizers; to provide new sources or amplify existing sources of contrast in cell and tissue imaging and to enable multiplexed optical biosensing; for light release of therapeutic agents such as drugs or genes; and as photosensitizers per se. Nanoparticles can also be used to enhance applications in the nano-radiation convergence, for example through increasing the effective radiation dose or increasing the oxygenation of tissue to overcome tumor hypoxia that limits tumor cell kill. In the radiation-photonics convergence, X-rays or radionuclides can be used to overcome the limited penetration of light in tissue that often hinders biophotonics applications, either by direct or Cherenkov-light mediated molecular excitation, thereby extending the capability of phototherapeutics and photodiagnostics. Finally, in the 3-way photonics-radiation-nano convergence, nanoparticles can further amplify ionizing radiation-optical interactions for treatment or imaging.

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