June 2-6, 2019
The convergence of photonics with nanotechnology and/or ionizing radiation offers new capabilities for biomedical applications. Thus, in the photonics-nano convergence, nanoparticles can be used for a range of purposes: to enhance or spatially localize light-based treatments such as in phototherapy or photodynamic therapy; for targeted delivery of photoactive drugs such as photodynamic sensitizers; to provide new sources or amplify existing sources of contrast in cell and tissue imaging and to enable multiplexed optical biosensing; for light release of therapeutic agents such as drugs or genes; and as photosensitizers per se. Nanoparticles can also be used to enhance applications in the nano-radiation convergence, for example through increasing the effective radiation dose or increasing the oxygenation of tissue to overcome tumor hypoxia that limits tumor cell kill. In the radiation-photonics convergence, X-rays or radionuclides can be used to overcome the limited penetration of light in tissue that often hinders biophotonics applications, either by direct or Cherenkov-light mediated molecular excitation, thereby extending the capability of phototherapeutics and photodiagnostics. Finally, in the 3-way photonics-radiation-nano convergence, nanoparticles can further amplify ionizing radiation-optical interactions for treatment or imaging.
Brian Wilson, "Radiation-optical interactions" in "Advances in Optics for Biotechnology, Medicine and Surgery XVI", Erin Buckley, Emory University/Georgia Institute of Technology, USA Christophe Moser, Polytechnique Fédérale de Lausanne (EPFL), Switzerland Brian Pogue, Dartmouth College, USA David Sampson, University of Western Australia, Australia Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/biotech_med_xvi/46