OCT for image-guided therapy and surgery
June 2-6, 2019
Image-guided therapy is a central enabling element for realization of precision medicine in the twenty-first century. Optical coherence tomography (OCT) can provide high-speed tomographic images of tissue with satisfactory contrast to differentiate blood flow, anomalous scattering constituents (e.g., tumors) and birefringent structures. In some cases, OCT can be integrated into an existing surgical workflow and benefit all stages of therapy including planning, real-time feedback control and post-treatment assessment. Today OCT is an integral component in some existing cardiovascular and ophthalmologic surgical workflows. An OCT-guided laser surgical system is presented for excision of brain tumors in an in vivo murine xenograft model. Precise and bloodless tumor resection under OCT image guidance is demonstrated so that tumor margins and vasculature are detected without exogenous contrast agents. The novel imaging capabilities and contrast provided by OCT can be utilized for more fundamental studies to investigate laser-tissue interactions in real-time. Two important laser-tissue interactions investigated with OCT are presented: laser coagulation of blood vessels and ablation of tissues. Study results demonstrate that OCT imaging of photocoagulation can enable a new understanding of important mechanisms relevant to laser photo-thermolysis of blood vessels. Similarly, OCT studies of the underlying mechanisms in laser tissue ablation motivate a novel approach for efficient and high-aspect ratio cutting for surgery.
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Thomas Milner, Arnold Estrada, Austin B. McElroy, and Nitesh Katta, "OCT for image-guided therapy and surgery" in "Advances in Optics for Biotechnology, Medicine and Surgery XVI", Erin Buckley, Emory University/Georgia Institute of Technology, USA Christophe Moser, Polytechnique Fédérale de Lausanne (EPFL), Switzerland Brian Pogue, Dartmouth College, USA David Sampson, University of Western Australia, Australia Eds, ECI Symposium Series, (2019). https://dc.engconfintl.org/biotech_med_xvi/47