Monitor and control of multiple bioreactor parameters using in situ raman spectroscopy
May 6-11, 2018
In situ Raman spectroscopy allows bioreactor parameters to be automatically measured online, multiple times per hour, while eliminating the need for sample removal. Raman spectra are used to develop predictive models for real-time measure of cell culture parameters. These models have been employed in development for superior process control of upstream bioprocesses. A case study of our approach will be discussed.
Michelle LaFond, "Monitor and control of multiple bioreactor parameters using in situ raman spectroscopy" in "Cell Culture Engineering XVI", A. Robinson, PhD, Tulane University R. Venkat, PhD, MedImmune E. Schaefer, ScD, J&J Janssen Eds, ECI Symposium Series, (2018). https://dc.engconfintl.org/ccexvi/113