CFD applications in bioreactor development and strategies for scaling up and down

Conference Dates

May 6-11, 2018


CFD (computational fluid dynamics) is becoming a common and practical tool for modeling the hydrodynamic environment of bioreactor processes. It can be used in addition to traditional methods to characterize fluid flow in production bioreactors in order to develop scale up and scale down models for enhanced transfer of processes from pilot to manufacturing scale. This poster will highlight CFD simulations and other traditional bioreactor characterization methods which have enabled better understanding of how scale up parameters, such as shear rate, power per unit volume (P/V), mixing time, and kLa affect cell culture processes and support Regeneron’s Quality by Design (QbD) efforts.

This document is currently not available here.