Development of an in silico molecule assessment method for product expression

Conference Dates

May 6-11, 2018


Protein products with expression-related manufacturability problems can present a significant barrier to the clinical and commercial feasibility of a project. Methods to identify and potentially eliminate poor-expressing therapeutic candidates early in the drug development process can simplify process development activities and facilitate platform fit, saving resources, costs and time. Existing experimental methods for screening expression level, such as transient transfection or stable pool yields, either lack the capability to accurately discriminate between candidates and/or they can be time-consuming, resource-intensive evaluations for multiple candidates. An in silico method was investigated with the goal of developing a more efficient and precise screening tool for determining expression level of therapeutic candidates.

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