Functionalized microcarriers for Enhanced CAR T cell manufacturing

Conference Dates

January 27-31, 2019


Adoptive cell therapy using chimeric antigen receptor (CAR) T cells has shown immense promise in treating cancer. In 2017, Novartis and Kite Pharma both acquired FDA approval for their CAR T cell therapies targeted toward B cell malignancies. Despite these successes, manufacturing high-quality T cells at scale has proven challenging. Notably, current processes rely on bead-based expansion and suspension-cell bioreactors, which do not recapitulate the high cell density and robust signaling found in the lymph nodes.

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