Large-scale stem cell production system by newly designed bioreactor
January 15-19, 2017
Large scale cell production system is required in drug discovery and cell based therapy. However there are technically challenges in maintaining high quality and low cost for practical biomanufacturing industry.
3D suspension culture is one of attractive process, especially static culture is ultimate free from shear force.
Utilizing static 3D suspension culture, automated closed system is newly designed and demonstrated expansion culture over several subcultures. Cell growth curves of this system and conventional manual method have good accordance. The system is also compatible with good scalability for scale up and scale out use.
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Hideaki Kagawa, Shun Goto, Mika Mifune, Soichi Kohashi, Tetsuya Yoshida, and Hidekazu Yamazaki, "Large-scale stem cell production system by newly designed bioreactor" in "Scale-up and Manufacturing of Cell-based Therapies V", Tom Brieva, Celgene Cellular Therapeutics William Miller, Northwestern University Chris Mason, University College London Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/cellbasedtherapies_v/53