Scaling viral vector production processes into HyPerforma DynaDrive Single-Use Bioreactors

Conference Dates

February 6 – 10, 2022


As viral vector gene therapy processes reach the clinical and manufacturing stages, the ability to scale up those processes becomes crucial. In this study we demonstrate how the Thermo Scientific HyPerforma DynaDrive Single-Use Bioreactor (S.U.B.) offers optimal conditions for growth and transfection of Gibco Viral Production Cells (VPC1.0 and VPC2.0 cells), both derivatives of HEK 293F cells, utilizing the Gibco LV-MAX Production System and the Gibco AAV-MAX Production System. We also show scalability of cell growth from flask to HyPerforma DynaDrive S.U.B. in 50L, 500L, and 3000L sizes, offering particular guidance on key scale factors and experience to ensure process success.

Poster 14.pdf (27 kB)

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