Organic-inorganic hybrid polymer coatings with controlled biofunctionality

Conference Dates

November 10-14, 2019


Fluorinated polyphosphazenes (FPs) offer important advantages as biocompatible coatings for coronary stents and other biomedical devices. Recently, a new class of FPs has been introduced, which integrates carboxylic1,2 or sulfonic acid3 and fluorinated moieties into a single macromolecular structure. Assemblies of such fluorinated polyelectrolytes with polyelectrolytes or charged small functional molecules can offer efficient modulation of hydrophobicity, improved biocompatibility, as well as biofunctionality, such as modulated drug release.

Here, we have explored aqueous multilayer polyelectrolyte deposition as a convenient route to nanofabrication of layered coatings built from ionic FPs (iFPs) and polyelectrolytes1,2 or small molecule partners. The resulting layer-by-layer (LbL) assemblies displayed controlled film growth, modulated hydrophobicity, swelling, and protein adsorption characteristics. Hydrophobic interactions largely contributed to the formation of LbL films of iFPs with polycations, leading to linear growth and extremely low water uptake. As shown in neutron reflectometry (NR) studies, films of fluorinated polyphospazenes demonstrated superior layering and persistence of such layering in salt solution as compared to control nonfluorinated polyphospha-zene/polycation films. Hydrophobicity-enhanced ionic pairing between iFP and linear polycations gave rise to large-amplitude oscillations in surface wettability as a function of capping layer. Importantly, hydrophobicity of iFP-capped LbL coatings could be further enhanced by using a highly porous polyester surgical felt rather than planar substrates for film deposition.2

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