In silico enzyme engineering - successful stories and future outlook
September 24-28, 2017
Part of the goals of the multi-partner INDOX European project (indoxproject.eu) was to identify, select and tailor oxidoreductases to obtain ad hoc industrial biocatalysts with optimized properties. Thanks to the combined effort of experimental and computational researchers we have successfully improved a variety of enzymatic processes including the industrial synthesis of: 1-naphthol1, 25-hydroxyvitamin D32, and conductive polyaniline3. The computational methodologies employed, in some design efforts, will be presented and the importance of fast and accurate computer-guided protein engineering solutions4,5 discussed.
Please click Additional Files below to see the full abstract.
Maria Fatima Lucas, "In silico enzyme engineering - successful stories and future outlook" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/enzyme_xxiv/102