In silico enzyme engineering - successful stories and future outlook

Conference Dates

September 24-28, 2017


Part of the goals of the multi-partner INDOX European project (indoxproject.eu) was to identify, select and tailor oxidoreductases to obtain ad hoc industrial biocatalysts with optimized properties. Thanks to the combined effort of experimental and computational researchers we have successfully improved a variety of enzymatic processes including the industrial synthesis of: 1-naphthol1, 25-hydroxyvitamin D32, and conductive polyaniline3. The computational methodologies employed, in some design efforts, will be presented and the importance of fast and accurate computer-guided protein engineering solutions4,5 discussed.

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