Engineering chitin deacetylases for the biotechnological production of patterned chitosans
September 24-28, 2017
Chitin processing, mainly in the form of depolymerization and de-N-acetylation reactions by chitin-modifiying enzymes (chitinases and deacetylases), generates a series of derivatives including chitosans and chitosan-oligosaccharides (COS), which play remarkable roles in Nature. COS are particularly involved in molecular recognition events, including the modulation of cell signaling and morphogenesis, the immune response, and host-pathogen interactions. Chitosans and COS are also attractive scaffolds for the development of bionanomaterials for drug/gene delivery and tissue engineering applications. Most of the biological activities associated with COS seem to be largely dependent not only on the degree of polymerization but also on the acetylation pattern, which defines the charge density and the distribution of GlcNAc and GlcNH2 moieties in chitosans and COS.
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Toni Planas, "Engineering chitin deacetylases for the biotechnological production of patterned chitosans" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/enzyme_xxiv/129