The fourth dimension: Accounting for dynamics when engineering enzymes
September 24-28, 2017
Despite key advances in enzyme engineering, our capacity to predict the effects of mutations on function remains nebulous. A central consideration in our incapacity to predict sequence-function relationships is the fact that proteins are dynamic, yet we rarely treat them as such.
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Joelle Pelletier, "The fourth dimension: Accounting for dynamics when engineering enzymes" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/enzyme_xxiv/160