Metabolic engineering of Saccharomyces cerevisiae to harness natures valuable compounds
September 24-28, 2017
Nature contains a treasure trove of small molecule ingredients that can improve health, wellness and nutrition. However, most of these ingredients have “issues”: the organism that makes the compound of interest is too rare, too hard to grow or does not make enough of it. Hence, the ingredient is not available at the right quality, the right price nor the necessary amount. These issues need to be solved in order to allow a larger society having access to these valuable ingredients in a sustainable manner at low costs. Evolva is leader in metabolic engineering of yeast for the production by fermentation of a diverse array of small molecule ingredients. The small molecule ingredients introduced to the market by Evolva include Resveratrol, Nootkatone, Valencene and Vanillin. Evolva and its commercial partner will launch the next-generation stevia sweetener EverSweetTM in 2018. All of these molecules are produced in a sustainable, reliable, cost-effective production at consistent quality by fermentation of engineered yeast strains, using abundant, inexpensive raw materials. Of particular interest to Evolva are the terpenes, which are known to work in a wide range of high value applications including sweeteners, flavors and fragrances, personal care, as well as human and animal health products. In spite of proven efficacy, there has been relatively little commercial development of terpene-based ingredients, mostly due to their high production cost. Here, we will present a number of terpene-based Evolva ingredient projects such as e.g. the stevia pathway, which use Evolva’s technology platforms, allowing us to produce these ingredients in an efficient and sustainable way.
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Christian Nyffenegger, Ângela Carvalho, Klavs Riishede Hansen, Esben Halkjær Hansen, Jørgen Hansen, Jean Amick, and Giovanni Salerno, "Metabolic engineering of Saccharomyces cerevisiae to harness natures valuable compounds" in "Enzyme Engineering XXIV", Pierre Monsan, Toulouse White Biotechnology, France Magali Remaud-Simeon, LISBP-INSA, University of Toulouse, France Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/enzyme_xxiv/30